New Drugs Could Help People Live To 150 Years

New Drugs Could Help People Live To 150 Years

Mar 11



By Lucy Crossley
Daily Mail
March 10, 2013

Original Link

Drugs that could combat ageing and help people to live to 150-years-old may be available within five years, following landmark research.

The new drugs are synthetic versions of resveratrol which is found in red wine and is believed to have an anti-ageing effect as it boosts activity of a protein called SIRT1.

Pharmaceutical giant GlaxoSmithKline has been testing the medications on patients suffering with medical conditions including cancer, diabetes and heart disease.

The work proves that a single anti-ageing enzyme in the body can be targeted, with the potential to prevent age-related diseases and extend lifespans.

As each of the 117 drugs tested work on the single enzyme through a common mechanism is means that a whole new class of anti-ageing drugs is now viable, which could ultimately prevent cancer, Alzheimer’s disease and type 2 diabetes.

Genetics professor David Sinclair, based at Harvard University, said: ‘Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others.

‘In effect, they would slow ageing.’

The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators.

The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed.

Although research surrounding resveratrol has been going on for a decade, until now the basic science had been contested.

Despite this, there have already been promising results in some trials with implications for cancer, cardiovascular disease and cardiac failure, type 2 diabetes, Alzheimer’s and Parkinson’s diseases, fatty liver disease, cataracts, osteoporosis, muscle wasting, sleep disorders and inflammatory diseases such as psoriasis, arthritis and colitis.

Professor Sinclair said: ‘In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster.’

The technology was sold to GlaxoSmithKline in 2008.

Four thousand synthetic activators, which are 100 times as potent as a single glass of red wine, have been developed — with the best three being used in human trials.

Writing in the journal Science, Professor Sinclair, who suggests the first therapeutic to be marketed will be for diabetes, said: ‘Our drugs can mimic the benefits of diet and exercise, but there is no impact on weight.’

Limited trials have been carried out in people with type 2 diabetes and the skin inflammatory disease, psoriasis.

Scientists found that there were benefits to the metabolism in the first group and a reduction in skin redness in the second.

The drugs can be administered orally, or topically.

So far, there have been no drugs developed to target ageing skin, but one major skin care range has developed a creme with resveratrol in it.

While any drug would be strictly prescribed for certain conditions, Professor Sinclair suggests that one day, they could be taken orally as a preventative.

They could therefore be used in the same way as statin drugs are commonly prescribed to prevent, instead of simply treating, cardiovascular disease.

In animal models, overweight mice given synthetic resveratrol were able to run twice as far as slim mice and they lived 15 per cent longer.

Professor Sinclair added: ‘Now we are looking at whether there are benefits for those who are already healthy.

‘Things there are also looking promising. We’re finding that ageing isn’t the irreversible affliction that we thought it was.

‘Some of us could live to 150, but we won’t get there without more research.’



Pulse on Aging & Anti-Aging



  1. Steve

    Let’s assume they are able to make such a drug. It would be a catastrophe. Probably only rich people could afford it, therefore creating one of the biggest class disparity.
    And if it was available to everybody…. are we going to work until we are 100 in order to afford 50 years of retirement?
    And how can possibly work until 100? Is the drug also keeping us young?
    I really hope this drug fails…

  2. Steve, this is a train that has already left the station. In my opinion, it’s only a matter of time before anti-aging drugs (and other age-reversal methods) are available to everyone. Yes, the rich will probably have access to these new age-reversal methods first. But it that will probably only last a couple weeks before some scrapper somewhere figures out how to mass produce them. Having a planet full of humans who don’t age, don’t die, and stay perpetually healthy will, however, obviously change everything. Personally, while we are bound to run into all kinds of problems when these technologies start exerting their influence, I think we’ll find a way to solve them. I’m looking forward to it and think it is a normal, healthy, natural part of the evolutionary trajectory we are on. If you haven’t heard it, you might find the future of the world that near-death experiencer Howard Storm describes very interesting: While this is probably only one of many, many possible futures, it’s one I personally resonate to…

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